Ciprofloxacin (Traveler's Diarrhea)

Overview

Traveler's diarrhea affects 30–70% of international travelers (CDC). Ciprofloxacin is effective against the most common bacterial causes including enterotoxigenic E. coli, Salmonella, and Shigella. It remains the CDC's primary recommendation for most destinations outside South/Southeast Asia.

It is typically used as a single 750 mg dose or 500 mg twice daily for 1–3 days. The CDC recommends self-treatment when diarrhea is incapacitating or accompanied by fever or bloody stools. Having a course on hand allows travelers to begin treatment immediately.

The CDC notes that fluoroquinolone resistance is increasing in South and Southeast Asia, where Azithromycin is preferred. For all other destinations — including Africa, Central/South America, and the Middle East — Ciprofloxacin remains a first-line option.

Wandr Health vs. a traditional travel clinic

Other travel medications

When travelers use this

• Trips to Africa, Central/South America, or the Middle East where TD risk is moderate to high
• Travelers who want a self-treatment option on hand for moderate-to-severe diarrhea
• Business travelers or those on tight itineraries who cannot afford days of illness
• Backpackers, adventure travelers, and cruise passengers visiting multiple ports

Compare with Azithromycin

The CDC recommends Azithromycin over Ciprofloxacin for travelers to South and Southeast Asia due to higher fluoroquinolone resistance rates. For all other regions, Ciprofloxacin remains a first-line option.

Related guides

Frequently asked questions